Data Science & Analytics
Validate a variant-effect predictor (AlphaMissense, ESM-C SAE, ESM logits, EVE, conservation scores, or any per-variant numeric score) against experimental deep mutational scanning (DMS) data. Computes per-variant predictor scores, splits variants into neutral vs disruptive groups by DMS effect, runs a Mann-Whitney U test on the predictor scores, and sweeps the stratification thresholds for robustness. Use when you need to know whether a predictor's scores track real functional disruption on a specific protein.
Publisher / source
mims-harvard/ToolUniverse (found on GitHub top repositories)
Upstream record
Version
Version 1
Published
2026-11-11
Publication review
Approved for publication
Content fingerprint
1a33bde1fd2a563750473b40ede4c4aa18696f0ca2613b665ef1026af7acb4db
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Source: https://prompeteer.ai/skills-hub/efc8ba4e-d5b8-42ae-bcba-796daa0fcb49