Medical & Healthcare
SolubleMPNN
Inverse-fold a backbone with SolubleMPNN — ProteinMPNN retrained on a soluble-PDB subset (Dauparas et al. 2022) — for sequences biased toward cytosolic expression and reduced aggregation. Reach for this skill when designs from vanilla ProteinMPNN are aggregating or going to inclusion bodies, when redesigning a membrane-adjacent fold for soluble expression, or when an E. coli expression screen is the next step.
- Publisher / source
- aipoch/open-science (found on GitHub top repositories)
- Upstream record
- aipoch/open-science
- Version
- Version 1
- Published
- Publication review
- Approved for publication
- Content fingerprint
c5c9b5cba2668bfafc54e899e5165a68e07a1425ab25667cab8c86807d3f6e0c